On 11th of June 2021, Jenna Najar at University of Gothenburg, defended her doctoral thesis entitled: “Risk factors for dementia – Lifestyle, hormones, neurochemistry, and genetics”.
The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Data used in this project were derived from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study).
Results from the thesis showed that married men had a reduced risk of dementia compared to unmarried men. Moreover, midlife cognitive and physical activity were independently associated with reduced risk of late-life dementia disorders. Also, longer reproductive periods and later age at menopause were associated with an increased risk of dementia and AD, particularly in those with dementia and AD onset after age 85 years. Further, longer reproductive periods were associated with cerebrospinal fluid (CSF) biomarkers for AD. Finally, polygenic risk scores for AD (AD-PRSs, including 39 and 57 genetic variants) and APOE genotype were associated with risk of dementia up to very old ages.
Read more: Jenna Najar, Thesis 2021
We are happy to announce that the National E-infrastructure for Aging Research (NEAR) received the research infrastructure grant 2021 by the Swedish Research Council (VR) for the project period from year 2023 to 2028. The purpose of the VR grant is to support already existing research infrastructures of national importance. Three years ago, the Swedish […]
NEAR is looking for a Database Coordinator who primarily will lead the work on metadata documentation. The primary task is to document collected data and verify that already documented data follows the correct format. The Database Coordinator will also lead the documentation performed by the other database managers and act as a project manager and […]
On 24th of May 2021, Harpa Sif Eyjólfsdóttir at Karolinska Institutet, defended her doctoral thesis entitled: “Unequal tracks? Studies in work, retirement and health” The overall aim of this thesis was to study how retirement is influenced by health status, socioeconomic position, and gender in Sweden; and in turn how the timing of exit from […]