On 11th of June 2021, Jenna Najar at University of Gothenburg, defended her doctoral thesis entitled: “Risk factors for dementia – Lifestyle, hormones, neurochemistry, and genetics”.
The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers for Alzheimer’s disease (AD). Data used in this project were derived from the Gothenburg H70 Birth Cohort Studies (H70-studies), the Prospective Population Study of Women (PPSW), and the Mayo Clinic Study of Aging (MCSA 70+ study).
Results from the thesis showed that married men had a reduced risk of dementia compared to unmarried men. Moreover, midlife cognitive and physical activity were independently associated with reduced risk of late-life dementia disorders. Also, longer reproductive periods and later age at menopause were associated with an increased risk of dementia and AD, particularly in those with dementia and AD onset after age 85 years. Further, longer reproductive periods were associated with cerebrospinal fluid (CSF) biomarkers for AD. Finally, polygenic risk scores for AD (AD-PRSs, including 39 and 57 genetic variants) and APOE genotype were associated with risk of dementia up to very old ages.
Read more: Jenna Najar, Thesis 2021
The Database Coordinator of NEAR, Alexander Darin-Mattsson presented NEAR at the 7th annual Big Data Conference at Linnaeus University Centre for Data Intensive Sciences and Applications (DISA) in Växjö, Sweden, 1 December 2021.
The Scientific Communicator of NEAR, Linnea Sjöberg, presented NEAR at the virtual morning coffee meeting with the Center for Alzheimer Research (CAR) at Karolinska Institutet (KI), 1 December 2021. The seminar rendered a lot of discussion on the possibilities and potential use of the NEAR data among the participating researchers.
NEAR’s third workshop entitled: ”Methodological issues in harmonizing and pooling of data” was conducted on-site, as well as online with 70 attending participants. It was chaired by Debora Rizzuto. After a short update and welcome addressed by Laura Fratiglioni, Alexander Darin-Mattsson and Xiaonan Hu presented how to conduct a study within NEAR and demonstrated the […]